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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-10-29
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pubmed:databankReference |
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pubmed:abstractText |
Mammalian noncoding microRNAs (miRNAs) are a class of gene regulators that have been linked to immune system function. Here, we have investigated the role of miR-155 during an autoimmune inflammatory disease. Consistent with a positive role for miR-155 in mediating inflammatory responses, Mir155(-/-) mice were highly resistant to experimental autoimmune encephalomyelitis (EAE). miR-155 functions in the hematopoietic compartment to promote the development of inflammatory T cells including the T helper 17 (Th17) cell and Th1 cell subsets. Furthermore, the major contribution of miR-155 to EAE was CD4(+) T cell intrinsic, whereas miR-155 was also required for optimum dendritic cell production of cytokines that promoted Th17 cell formation. Our study shows that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR-155 might be a promising therapeutic target for the treatment of autoimmune disorders.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1097-4180
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
607-19
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pubmed:dateRevised |
2011-10-31
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pubmed:meshHeading |
pubmed-meshheading:20888269-Animals,
pubmed-meshheading:20888269-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20888269-Cells, Cultured,
pubmed-meshheading:20888269-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:20888269-Glycoproteins,
pubmed-meshheading:20888269-Hypersensitivity, Delayed,
pubmed-meshheading:20888269-Interferon-gamma,
pubmed-meshheading:20888269-Interleukin-17,
pubmed-meshheading:20888269-Mice,
pubmed-meshheading:20888269-Mice, Inbred C57BL,
pubmed-meshheading:20888269-MicroRNAs,
pubmed-meshheading:20888269-Peptide Fragments
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pubmed:year |
2010
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pubmed:articleTitle |
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.
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pubmed:affiliation |
Division of Biology, California Institute of Technology, 330 Braun, 1200 E. California Boulevard, Pasadena, CA 91125, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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