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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-10-5
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pubmed:abstractText |
Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10(-15) in the initial sample, p = 6.58 × 10(-39) in the second genome-wide sample, and p = 2.12 × 10(-32) in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10(-83). The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10(-58)) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-10845877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-11479627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-12611609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-12878598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-14752031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-15210937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-15509809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-16380500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-17391153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-17786212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-18316604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-18502270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-19088327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-19165155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-19396169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-20011104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-20018283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-20067957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887962-9877251
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1537-6605
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pubmed:author |
pubmed-author:BaikInkyungI,
pubmed-author:BeatyTerri HTH,
pubmed-author:ChoEun-YoungEY,
pubmed-author:JangYangsooY,
pubmed-author:JeeEun JungEJ,
pubmed-author:JeeSun HaSH,
pubmed-author:KaoLindaL,
pubmed-author:KimSang YeunSY,
pubmed-author:KimmHeejinH,
pubmed-author:LeeJong-EunJE,
pubmed-author:LeeSun JuSJ,
pubmed-author:ParkJi WanJW,
pubmed-author:ParkJongkeunJ,
pubmed-author:ShinCholC,
pubmed-author:ShinEun-SoonES,
pubmed-author:SullJae WoongJW,
pubmed-author:YoonSungjoo KimSK,
pubmed-author:YunJi EunJE
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pubmed:copyrightInfo |
Copyright © 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
545-52
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20887962-Adiponectin,
pubmed-meshheading:20887962-Adult,
pubmed-meshheading:20887962-Asian Continental Ancestry Group,
pubmed-meshheading:20887962-Blood Pressure,
pubmed-meshheading:20887962-Body Mass Index,
pubmed-meshheading:20887962-Cadherins,
pubmed-meshheading:20887962-Cell Line,
pubmed-meshheading:20887962-Cholesterol,
pubmed-meshheading:20887962-DNA Primers,
pubmed-meshheading:20887962-Female,
pubmed-meshheading:20887962-Genome-Wide Association Study,
pubmed-meshheading:20887962-Genotype,
pubmed-meshheading:20887962-Humans,
pubmed-meshheading:20887962-Linkage Disequilibrium,
pubmed-meshheading:20887962-Male,
pubmed-meshheading:20887962-Middle Aged,
pubmed-meshheading:20887962-Polymorphism, Single Nucleotide,
pubmed-meshheading:20887962-Promoter Regions, Genetic,
pubmed-meshheading:20887962-Sequence Analysis, DNA
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pubmed:year |
2010
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pubmed:articleTitle |
Adiponectin concentrations: a genome-wide association study.
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pubmed:affiliation |
Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 102-752, South Korea. jsunha@yuhs.ac
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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