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rdf:type |
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lifeskim:mentions |
umls-concept:C0021289,
umls-concept:C0031327,
umls-concept:C0033572,
umls-concept:C0034715,
umls-concept:C0053800,
umls-concept:C0229671,
umls-concept:C0332157,
umls-concept:C0442027,
umls-concept:C0443315,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1709160,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2011-2-8
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pubmed:abstractText |
The present study examines BPA pharmacokinetics in neonatal rats following s.c. injection or oral delivery of 10 ?g BPA/kg BW and compares susceptibility to estrogen-induced prostate intraepithelial neoplasia (PIN) following either exposure route. Serum BPA in PND3 rats was measured using HPLC-MS-MS. Free and total BPA at C(max) were 1.77 and 2.0 ng/ml, respectively following injection and 0.26 and 1.02 ng/ml, respectively following oral exposure. The AUC(0-2) for free and total BPA was 4.1-fold and 1.8-fold greater, respectively, in s.c. vs. oral delivery. While exposure route affected BPA metabolism, internal dosimetry following s.c. injection of 10 ?g BPA/kg BW is similar to BPA levels observed in humans. Prostates from aged rats given s.c. or oral BPA neonatally and T+E implants as adults exhibited nearly identical, heightened susceptibility to PIN incidence and score as compared to neonatal oil-controls. These findings on prostate health are directly relevant to humans at current BPA exposure levels.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-10333482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-10595928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-10919363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-11836149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-12207000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-12586156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-14691203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-15099732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-15901667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-16123166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-16930674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-17123779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-17261752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-18656671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-19528054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-20334893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-7788848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20887781-8504731
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1873-1708
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-9
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pubmed:dateRevised |
2011-10-11
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pubmed:meshHeading |
pubmed-meshheading:20887781-Administration, Oral,
pubmed-meshheading:20887781-Animals,
pubmed-meshheading:20887781-Animals, Newborn,
pubmed-meshheading:20887781-Estrogens, Non-Steroidal,
pubmed-meshheading:20887781-Injections, Subcutaneous,
pubmed-meshheading:20887781-Male,
pubmed-meshheading:20887781-Phenols,
pubmed-meshheading:20887781-Prostatic Intraepithelial Neoplasia,
pubmed-meshheading:20887781-Prostatic Neoplasms,
pubmed-meshheading:20887781-Rats,
pubmed-meshheading:20887781-Rats, Sprague-Dawley
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pubmed:year |
2011
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pubmed:articleTitle |
Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats.
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pubmed:affiliation |
Department of Urology, 820 S Wood St, MC 955, University of Illinois at Chicago, Chicago, IL 60612, USA. gprins@uic.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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