Linked Life Data

20887709

Source:http://linkedlifedata.com/resource/pubmed/id/20887709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-8
pubmed:abstractText
Prenatal malnutrition is responsible for the onset of alterations in renal Na(+) transport in the adult offspring. Here we investigated the molecular mechanisms by which increased formation of reactive oxygen species during prenatal malnutrition affects the pathways that couple angiotensin II (Ang II) receptors (AT(1)R and AT(2)R) to kidney Na(+)-ATPase in adulthood, and how maternal treatment with ?-tocopherol can prevent alterations in the main regulatory cascade of the pump. The experiments were carried out on the adult progeny of control and malnourished dams during pregnancy that did or did not receive ?-tocopherol during lactation. Malnutrition during pregnancy increased maternal hepatic and adult offspring renal malondialdehyde levels, which returned to control after supplementation with ?-tocopherol. In the adult offspring, placental malnutrition programmed: decrease in Na(+)-ATPase activity, loss of the physiological stimulation of this pump by Ang II, up-regulation of AT(1)R and AT(2)R, decrease in membrane PKC activity, selective decrease of the PKC? isoform expression, and increase in PKA activity with no change in PKA ?-catalytic subunit expression. These alterations were reprogrammed to normal levels by ?-tocopherol during lactation. The influence of ?-tocopherol on the signaling machinery in adult offspring indicates selective non-antioxidant effects at the gene transcription and protein synthesis levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1096-0384
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
505
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-7
pubmed:meshHeading
pubmed-meshheading:20887709-Adenosine Triphosphatases, pubmed-meshheading:20887709-Animals, pubmed-meshheading:20887709-Cation Transport Proteins, pubmed-meshheading:20887709-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:20887709-Female, pubmed-meshheading:20887709-Gene Expression Regulation, pubmed-meshheading:20887709-Kidney, pubmed-meshheading:20887709-Lactation, pubmed-meshheading:20887709-Malnutrition, pubmed-meshheading:20887709-Placenta, pubmed-meshheading:20887709-Pregnancy, pubmed-meshheading:20887709-Protein Kinase C, pubmed-meshheading:20887709-Rats, pubmed-meshheading:20887709-Rats, Wistar, pubmed-meshheading:20887709-Reactive Oxygen Species, pubmed-meshheading:20887709-Receptor, Angiotensin, Type 1, pubmed-meshheading:20887709-Receptors, Angiotensin, pubmed-meshheading:20887709-alpha-Tocopherol
pubmed:year
2011
pubmed:articleTitle
Placental malnutrition changes the regulatory network of renal Na-ATPase in adult rat progeny: Reprogramming by maternal ?-tocopherol during lactation.
pubmed:affiliation
Department of Physiology and Pharmacology, Center of Biological Sciences, Federal University of Pernambuco, Recife, Brazil; National Institute of Science and Technology for Structural Biology and Bioimaging, Rio de Janeiro, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't