Linked Life Data

20887559

Source:http://linkedlifedata.com/resource/pubmed/id/20887559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-10-4
pubmed:abstractText
A gene, sunB, encoding a novel class of Sad1 and UNC-84 (SUN) domain, was isolated from a cDNA screen for suppressors of a mutation in Dd-STATa - a Dictyostelium homologue of metazoan STAT (signal transducers and activators of transcription). The SunB protein localized in the area around the nucleus in growing cells, but in the multicellular stages it was predominantly found in prespore vacuoles (PSVs). A disruptant of sunB was multinucleated in the vegetative phase; during development it formed mounds with multiple tips and failed to culminate. The mutation was cell autonomous, and showed reduced expression of the prespore marker gene pspA and elevated expression of marker genes for prestalk AB cells. Interestingly, the level of SunB was abnormally high in the prestalk cells of Dd-STATa mutants, which are defective in culmination. We conclude that SunB is essential for accurate prestalk/prespore differentiation during Dictyostelium development and that its cell-type dependent localization is regulated by a Dd-STATa-mediated signaling pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1440-169X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
577-90
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
SunB, a novel Sad1 and UNC-84 domain-containing protein required for development of Dictyostelium discoideum.
pubmed:affiliation
Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't