Linked Life Data

20887390

Source:http://linkedlifedata.com/resource/pubmed/id/20887390

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-11-22
pubmed:abstractText
The immunohistochemical (IHC) localization of oestrogen receptor alpha (ER?) was studied in the developing left ovary of 14.5-day-old chick embryos. The study was focused in particular on distinguishing in cortex and medulla the different cell categories that proved positive to the reaction, in order to gain further understanding of gonadal cell interactions during ovarian development. Immunostained cells were observed in both the cortex and medulla, but the reactivity for ER? was discontinuous, probably due to variable cell requirements. In the cortex, positivity was observed in cells of the ovarian surface epithelium, in germ cells and in prefollicular cells. In the medulla, positivity was found in the following cell categories: interstitial cells, poorly differentiated somatic cord cells, including those delimiting lacunae, germ cells and their accompanying cells of epithelial origin. Furthermore, the IHC results showed that the intracellular localization of the antigen was cytoplasmic, nuclear, or both. The significance of ER? presence and intracellular localization was discussed in relation and as supplementary to previous research by various Authors. In particular, as regards the unusual cytoplasmic immunoreactivity, a gradual shift of ER? localization from cytoplasmic to nuclear during the embryonic period is suggested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1439-0264
pubmed:author
pubmed:copyrightInfo
© 2010 Blackwell Verlag GmbH.
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
546-54
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Immunohistochemical localization of oestrogen receptor alpha in the various cell categories of chick embryo ovary.
pubmed:affiliation
Department of Biology and Biotechnologies, Charles Darwin University of Rome, Viale dell'Università 32, 00185 Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't