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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1991-5-30
|
| pubmed:abstractText |
We have reviewed our experience with acute interstitial nephritis (AIN) in pediatric patients over the 3-year period from 1985 to 1988. We encountered 7 new cases of AIN in this interval and it was seen in 7% of kidney biopsies performed during this time of study. The clinical presentation was very nonspecific and included fever (100%), gastrointestinal complaints (57%) and rash (28%). Laboratory findings on admission included elevated erythrocyte sedimentation rate (100%), anemia (70%), pyuria (57%) and abnormal renal ultrasound (86%). Associated systemic diseases were observed in 4 patients. AIN was severe enough to necessitate treatment with hemodialysis in 42% of the cases. Corticosteroid therapy was used in 6 patients with a favorable response in all but 1 case. While 6/7 patients manifested complete recovery, 1 adolescent who may have had pre-existing renal disease had persistent chronic renal failure (estimated GFR, 25 l/min/1.73 m2). We have concluded that: (1) AIN is a relatively common disease in pediatric practice; (2) it can be severe enough to necessitate dialysis therapy, and (3) AIN often occurs in children with systemic disorders that may be associated with immunologic disorders.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1012-6694
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
189-95
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2088589-Adolescent,
pubmed-meshheading:2088589-Adult,
pubmed-meshheading:2088589-Child,
pubmed-meshheading:2088589-Female,
pubmed-meshheading:2088589-Fluorescent Antibody Technique,
pubmed-meshheading:2088589-Humans,
pubmed-meshheading:2088589-Incidence,
pubmed-meshheading:2088589-Kidney,
pubmed-meshheading:2088589-Kidney Glomerulus,
pubmed-meshheading:2088589-Male,
pubmed-meshheading:2088589-Nephritis, Interstitial,
pubmed-meshheading:2088589-New York,
pubmed-meshheading:2088589-T-Lymphocyte Subsets
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Acute interstitial nephritis in adolescents and young adults.
|
| pubmed:affiliation |
Department of Pediatrics (Division of Nephrology), Schneider Children's Hospital of Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, N.Y.
|
| pubmed:publicationType |
Journal Article
|