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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-11-8
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pubmed:abstractText |
The immunopathogenesis of type I autoimmune hepatitis (AIH-I) might involve the deregulation of different cellular processes. Here, we investigated the liver expression of selected cytokines and genes of regulatory cell populations in children both at diagnosis and during biochemical remission following immunosuppressive treatment (AIH-Ir). We found a higher V?24, IFN-?, FoxP3, IL-27p28, IL-12p40 and IL-21 expression at diagnosis as well as a positive correlation between IL-21 and transaminase levels. Interestingly, only IFN-? and FoxP3 were decreased in AIH-Ir. An "AIH-I phenotype" (high V?24, IFN-? and FoxP3 expression at diagnosis) was observed in only 5 out of 22 AIH-Ir patients but not in controls. These results indicate a local deregulation of the innate and adaptive immune responses with an increased transcriptional activity of immunoregulatory cells at diagnosis. In addition, IL-21 is highlighted as a mediator of liver injury. AIH-Ir is characterized by a partial reversal of the deregulated response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/IL27 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12 Subunit p40,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Transaminases,
http://linkedlifedata.com/resource/pubmed/chemical/Valpha24 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-21
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1521-7035
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
396-405
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pubmed:meshHeading |
pubmed-meshheading:20884299-Adolescent,
pubmed-meshheading:20884299-Biological Markers,
pubmed-meshheading:20884299-Child,
pubmed-meshheading:20884299-Child, Preschool,
pubmed-meshheading:20884299-Female,
pubmed-meshheading:20884299-Forkhead Transcription Factors,
pubmed-meshheading:20884299-Gene Expression Regulation,
pubmed-meshheading:20884299-Hepatitis, Autoimmune,
pubmed-meshheading:20884299-Humans,
pubmed-meshheading:20884299-Interferon-gamma,
pubmed-meshheading:20884299-Interleukin-12 Subunit p40,
pubmed-meshheading:20884299-Interleukins,
pubmed-meshheading:20884299-Liver,
pubmed-meshheading:20884299-Male,
pubmed-meshheading:20884299-Polymerase Chain Reaction,
pubmed-meshheading:20884299-RNA, Messenger,
pubmed-meshheading:20884299-Receptors, Antigen, T-Cell,
pubmed-meshheading:20884299-Transaminases
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pubmed:year |
2010
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pubmed:articleTitle |
The simultaneous high expression of V?24, IFN-? and FoxP3 characterizes the liver of children with type I autoimmune hepatitis.
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pubmed:affiliation |
División Inmunogenética, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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