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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2010-10-18
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pubmed:abstractText |
An efficient synthesis has provided access to a novel ?-tocopherol analogue (2), as well as its trifluoroacetate salt and acetate ester. An annulation reaction was used to establish the pyridinol core structure and a Stille coupling reaction was employed for conjugation with the tocopherol side chain. This analogue was shown to suppress the levels of reactive oxygen species in cultured cells, and to quench peroxidation of mitochondrial membranes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7628-38
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pubmed:meshHeading |
pubmed-meshheading:20884213-Animals,
pubmed-meshheading:20884213-Antioxidants,
pubmed-meshheading:20884213-Cattle,
pubmed-meshheading:20884213-Cell Membrane,
pubmed-meshheading:20884213-Diterpenes,
pubmed-meshheading:20884213-Drug Design,
pubmed-meshheading:20884213-Lipid Peroxidation,
pubmed-meshheading:20884213-Mitochondria,
pubmed-meshheading:20884213-Pyridines,
pubmed-meshheading:20884213-Pyrimidines,
pubmed-meshheading:20884213-Pyrroles,
pubmed-meshheading:20884213-Reactive Oxygen Species,
pubmed-meshheading:20884213-alpha-Tocopherol
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pubmed:year |
2010
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pubmed:articleTitle |
Design, synthesis, and evaluation of an ?-tocopherol analogue as a mitochondrial antioxidant.
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pubmed:affiliation |
Center for BioEnergetics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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