rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2-3
|
pubmed:dateCreated |
1990-5-17
|
pubmed:databankReference |
|
pubmed:abstractText |
A cDNA encoding the nucleic acid-binding domain of the hnRNP C-type protein has been cloned by DNA-affinity screening of pituitary-derived expression libraries. An analysis revealed sequence identity with the human C-type cDNA and demonstrated the presence of a peptide sequence contained within the single-stranded DNA-binding protein, UP2, which was absent from the human cDNA. Structural analysis of the protein encoded by the rat cDNA demonstrated a net charge of +15 with 14.56% and 6.33% lysines and arginines, respectively, and an amino acid sequence that is consistent with an extensive helix-loop-helix-turn-helix structure.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0006-3002
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
1048
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
306-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2088340-Amino Acid Sequence,
pubmed-meshheading:2088340-Animals,
pubmed-meshheading:2088340-Base Sequence,
pubmed-meshheading:2088340-Cloning, Molecular,
pubmed-meshheading:2088340-DNA,
pubmed-meshheading:2088340-DNA-Binding Proteins,
pubmed-meshheading:2088340-Gene Library,
pubmed-meshheading:2088340-Heterogeneous-Nuclear Ribonucleoprotein Group C,
pubmed-meshheading:2088340-Heterogeneous-Nuclear Ribonucleoproteins,
pubmed-meshheading:2088340-Humans,
pubmed-meshheading:2088340-Molecular Sequence Data,
pubmed-meshheading:2088340-Pituitary Gland,
pubmed-meshheading:2088340-Protein Conformation,
pubmed-meshheading:2088340-Rats,
pubmed-meshheading:2088340-Ribonucleoproteins
|
pubmed:year |
1990
|
pubmed:articleTitle |
Cloning of the nucleic acid-binding domain of the rat HnRNP C-type protein.
|
pubmed:affiliation |
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-78284.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|