Linked Life Data

20881849

Source:http://linkedlifedata.com/resource/pubmed/id/20881849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-10-27
pubmed:abstractText
Most cervical adenocarcinomas are of the so-called usual or endocervical type, and consist entirely or predominantly of glandular formations. We describe 3 cases of an unusual morphologic variant of cervical adenocarcinoma largely composed of bland epithelial cells, with occasional intracytoplasmic lumina, arranged in a variety of architectural patterns, including diffuse, small glandular, insular, trabecular, and Indian file arrangements. The overall appearances closely resembled a breast lobular carcinoma. In all cases, there was a minor superficial component of well-differentiated adenocarcinoma, suggesting that the component that resembled breast lobular carcinoma, arose from the differentiated neoplasm. All cases were diffusely p16-positive, and 2 that underwent human papillomavirus testing contained high-risk oncogenic human papillomavirus, type 16 and 18 in 1 case each. In all cases, there was loss of e-cadherin membranous immunoreactivity in the areas resembling breast lobular carcinoma, a similar pattern of staining to that seen in the latter neoplasm and possibly accounting for the morphologic features. In 2 cases, there was extracervical spread, including distant lymph node metastasis in 1. In reporting these cases, we highlight an unusual morphologic variant of cervical adenocarcinoma closely resembling breast lobular carcinoma and which may have an aggressive behavior.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1538-7151
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
594-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Cervical adenocarcinoma resembling breast lobular carcinoma: a hitherto Undescribed Variant of Primary Cervical Adenocarcinoma.
pubmed:affiliation
Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland.
pubmed:publicationType
Journal Article, Case Reports