Linked Life Data

2088007

Source:http://linkedlifedata.com/resource/pubmed/id/2088007

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-5-23
pubmed:abstractText
Anti-inflammatory effects of calcium antagonists verapamil (Ver), nifedipine (Nif) and nicardipine (Nic) were compared. They all produced significant inhibitions in acute and chronic inflammatory models in a dose-dependent manner. The ED30 in the capillary permeability were: Ver 18, Nif 12 and Nic 8 mg/kg, respectively. In the xylene-induced swelling of mouse ears, the ED30 were: Ver 39, Nif 14, and Nic 25 mg/kg, respectively. In the carrageenan paw edema of mice, and in the acetic acid-induced pleurisy and cotton granuloma of rats these drugs inhibited inflammatory responses at 5 or 10 mg/kg. Nif showed a greater effect than Ver and Nic on the paw edema, and Ver showed greater effects than NIf and Nic on the pleurisy and granuloma. At 10 mg/kg they depressed the PGE2 content measured by radioimmunoassay in inflammatory tissues of carrageenan paw edema of mice.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Anti-inflammatory effects of verapamil, nifedipine and nicardipine].
pubmed:affiliation
Department of Pharmacology, Xinjiang Medical College, Urümqi, China.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't