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rdf:type |
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lifeskim:mentions |
umls-concept:C0009325,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0185117,
umls-concept:C0215848,
umls-concept:C0242184,
umls-concept:C0302600,
umls-concept:C0333562,
umls-concept:C0851285,
umls-concept:C2340138,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-4
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pubmed:abstractText |
Several studies have shown that regions of hypoxia develop in the liver during chronic injury. Furthermore, it has been demonstrated that hypoxia stimulates the release of mediators from hepatic stellate cells (HSCs) that may affect the progression of fibrosis. The mechanism by which hypoxia modulates gene expression in HSCs is not known. Recent studies demonstrated that the hypoxia-activated transcription factor, hypoxia-inducible factor (HIF)-1?, is critical for the development of fibrosis. Accordingly, the hypothesis was tested that HIF-1? is activated in HSCs and regulates the expression of genes important for HSC activation and liver fibrosis.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Ccr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-13 Receptor alpha1...,
http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Migration-Inhibitory...,
http://linkedlifedata.com/resource/pubmed/chemical/Mif protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/endothelial PAS domain-containing...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1478-3231
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 John Wiley & Sons A/S.
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
230-44
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pubmed:dateRevised |
2011-5-24
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pubmed:meshHeading |
pubmed-meshheading:20880076-Animals,
pubmed-meshheading:20880076-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:20880076-Blotting, Western,
pubmed-meshheading:20880076-Cell Hypoxia,
pubmed-meshheading:20880076-DNA Primers,
pubmed-meshheading:20880076-Gene Expression Regulation,
pubmed-meshheading:20880076-Hepatic Stellate Cells,
pubmed-meshheading:20880076-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:20880076-Interleukin-13 Receptor alpha1 Subunit,
pubmed-meshheading:20880076-Intramolecular Oxidoreductases,
pubmed-meshheading:20880076-Liver Cirrhosis,
pubmed-meshheading:20880076-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:20880076-Male,
pubmed-meshheading:20880076-Mice,
pubmed-meshheading:20880076-Mice, Inbred C57BL,
pubmed-meshheading:20880076-Microarray Analysis,
pubmed-meshheading:20880076-Receptors, CCR1,
pubmed-meshheading:20880076-Receptors, CCR5,
pubmed-meshheading:20880076-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2011
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pubmed:articleTitle |
Hypoxia-inducible factor-1? regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis.
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pubmed:affiliation |
Department of Pharmacology, Toxicology, and Experimental Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA. bcopple@kumc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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