|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1991-5-23
|
|
pubmed:abstractText |
The excitatory actions on the unit activities of locus coeruleus induced by excitatory amino acids were studied. Quinolinic acid 10 nmol and N-methyl-D-aspartate (NMDA) 4 nmol icv markedly increased unit discharge of locus coeruleus neurons. The excitatory action was fully antagonized by icv 4 nmol D,L-2-amino-7-phosphonoheptanoic acid, a specific NMDA receptor antagonist. Excitatory effect induced by quinolinic acid is possibly mediated by excitatory amino acid receptors in locus coeruleus.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0253-9756
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
193-5
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2087991-2-Amino-5-phosphonovalerate,
pubmed-meshheading:2087991-Amino Acids,
pubmed-meshheading:2087991-Animals,
pubmed-meshheading:2087991-Anticonvulsants,
pubmed-meshheading:2087991-Electrophysiology,
pubmed-meshheading:2087991-Glutamates,
pubmed-meshheading:2087991-Locus Coeruleus,
pubmed-meshheading:2087991-Male,
pubmed-meshheading:2087991-N-Methylaspartate,
pubmed-meshheading:2087991-Neurons,
pubmed-meshheading:2087991-Quinolinic Acids,
pubmed-meshheading:2087991-Rats,
pubmed-meshheading:2087991-Rats, Inbred Strains
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Modulation of neuronal activity of locus coeruleus in rats induced by excitatory amino acids.
|
|
pubmed:affiliation |
Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
