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pubmed-article:20879879pubmed:abstractTextSpleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy.lld:pubmed
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pubmed-article:20879879pubmed:articleTitleAn oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis.lld:pubmed
pubmed-article:20879879pubmed:affiliationDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. mweinblatt@partners.orglld:pubmed
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