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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0035322,
umls-concept:C0052927,
umls-concept:C0078058,
umls-concept:C0086418,
umls-concept:C0162772,
umls-concept:C0165519,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0242606,
umls-concept:C1171892,
umls-concept:C2911684
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|
pubmed:issue |
5
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pubmed:dateCreated |
2010-10-7
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pubmed:abstractText |
Age-related macular degeneration is a leading cause of blindness in the elderly. At a later stage, neovascular or exudative age-related macular degeneration can lead to severe central vision loss that is related to aging-associated cumulative oxidative stress of the human retinal pigment epithelium (hRPE) cells. Early prevention with antioxidants is mandatory. The aim of this study was to determine whether and how baicalein can act as an antioxidant.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1557-7732
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pubmed:author |
pubmed-author:ChaoFang-PingFP,
pubmed-author:ChaoHsiao-MingHM,
pubmed-author:ChenMi-MiMM,
pubmed-author:ChenYei-ChingYC,
pubmed-author:ChuangHui-YenHY,
pubmed-author:LiuChi-MingCM,
pubmed-author:LiuJorn-HonJH,
pubmed-author:PanWynn H TWH,
pubmed-author:TsaiShen-KouSK,
pubmed-author:WannHsiungH,
pubmed-author:YehMing-YangMY,
pubmed-author:YoungMason ShingMS
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pubmed:issnType |
Electronic
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pubmed:volume |
26
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-9
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pubmed:meshHeading |
pubmed-meshheading:20879805-Antioxidants,
pubmed-meshheading:20879805-Cell Survival,
pubmed-meshheading:20879805-Dose-Response Relationship, Drug,
pubmed-meshheading:20879805-Down-Regulation,
pubmed-meshheading:20879805-Flavanones,
pubmed-meshheading:20879805-Humans,
pubmed-meshheading:20879805-Hydrogen Peroxide,
pubmed-meshheading:20879805-Macular Degeneration,
pubmed-meshheading:20879805-Matrix Metalloproteinase 9,
pubmed-meshheading:20879805-Oxidative Stress,
pubmed-meshheading:20879805-Reactive Oxygen Species,
pubmed-meshheading:20879805-Retinal Pigment Epithelium,
pubmed-meshheading:20879805-Vascular Endothelial Growth Factor A
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pubmed:year |
2010
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pubmed:articleTitle |
Baicalein significantly protects human retinal pigment epithelium cells against H?O?-induced oxidative stress by scavenging reactive oxygen species and downregulating the expression of matrix metalloproteinase-9 and vascular endothelial growth factor.
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pubmed:affiliation |
Department of Ophthalmology, Cheng Hsin General Hospital , Taipei, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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