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rdf:type |
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lifeskim:mentions |
umls-concept:C0001779,
umls-concept:C0003402,
umls-concept:C0014442,
umls-concept:C0017431,
umls-concept:C0020275,
umls-concept:C0023516,
umls-concept:C0178693,
umls-concept:C0205485,
umls-concept:C0206243,
umls-concept:C0220931,
umls-concept:C0242606,
umls-concept:C0678951,
umls-concept:C1280500
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pubmed:issue |
6
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pubmed:dateCreated |
2010-10-19
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pubmed:abstractText |
Reactive oxygen species account for the background levels of oxidatively damaged DNA in normal tissues. Physical exercise increases oxygen consumption and can cause oxidative stress. This stress can also involve deficient antioxidant defenses, which can be influenced by certain genetic polymorphisms. Because regular exercise is a known inducer of antioxidant enzymes, the objective of this study was to compare, by comet assay, differences in the DNA damage between apparently healthy individuals and trained aerobic sportsmen carrying the same single nucleotide polymorphisms of manganese superoxide dismutase (Val9Ala), catalase (-21A/T), glutathione peroxidase 1 (Pro198Leu), before and after exposing leukocytes from peripheral blood to hydrogen peroxide (H?O?).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1520-6300
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
807-12
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pubmed:dateRevised |
2011-3-16
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pubmed:meshHeading |
pubmed-meshheading:20878976-Adolescent,
pubmed-meshheading:20878976-Adult,
pubmed-meshheading:20878976-Age Factors,
pubmed-meshheading:20878976-Athletes,
pubmed-meshheading:20878976-Catalase,
pubmed-meshheading:20878976-DNA Damage,
pubmed-meshheading:20878976-Exercise,
pubmed-meshheading:20878976-Female,
pubmed-meshheading:20878976-Genotype,
pubmed-meshheading:20878976-Glutathione Peroxidase,
pubmed-meshheading:20878976-Humans,
pubmed-meshheading:20878976-Hydrogen Peroxide,
pubmed-meshheading:20878976-Leukocytes,
pubmed-meshheading:20878976-Male,
pubmed-meshheading:20878976-Middle Aged,
pubmed-meshheading:20878976-Oxidative Stress,
pubmed-meshheading:20878976-Physical Fitness,
pubmed-meshheading:20878976-Polymorphism, Single Nucleotide,
pubmed-meshheading:20878976-Sex Factors,
pubmed-meshheading:20878976-Superoxide Dismutase
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pubmed:articleTitle |
The effect of hydrogen peroxide-induced oxidative stress on leukocytes depends on age and physical training in healthy human subjects carrying the same genotypes of antioxidant enzymes' gene polymorphisms.
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pubmed:affiliation |
Departamento de Genética e Morfologia, Laboratório de Genética, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Brasília/DF, Brazil. mirandavilela@unb.br
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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