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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-12
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pubmed:abstractText |
Gene-environment interplay modulates inflammatory bowel diseases (IBD). Dioxin-like compounds can activate the aryl hydrocarbon receptor (AhR) and alter macrophage function as well as T-cell polarization. We hypothesized that attenuation of the AhR signaling pathway will ameliorate colitis in a murine model of IBD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AHR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Ahr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Aryl Hydrocarbon,
http://linkedlifedata.com/resource/pubmed/chemical/Xenobiotics,
http://linkedlifedata.com/resource/pubmed/chemical/adiponectin, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1536-4844
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1149-62
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pubmed:dateRevised |
2011-10-20
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pubmed:meshHeading |
pubmed-meshheading:20878756-Adiponectin,
pubmed-meshheading:20878756-Animals,
pubmed-meshheading:20878756-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:20878756-Biopsy,
pubmed-meshheading:20878756-Colitis,
pubmed-meshheading:20878756-Disease Models, Animal,
pubmed-meshheading:20878756-Genotype,
pubmed-meshheading:20878756-Humans,
pubmed-meshheading:20878756-Inflammatory Bowel Diseases,
pubmed-meshheading:20878756-Mice,
pubmed-meshheading:20878756-Mice, Inbred C57BL,
pubmed-meshheading:20878756-Mice, Mutant Strains,
pubmed-meshheading:20878756-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:20878756-Severity of Illness Index,
pubmed-meshheading:20878756-Signal Transduction,
pubmed-meshheading:20878756-Th1 Cells,
pubmed-meshheading:20878756-Th17 Cells,
pubmed-meshheading:20878756-Th2 Cells,
pubmed-meshheading:20878756-Xenobiotics
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pubmed:year |
2011
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pubmed:articleTitle |
Role of the xenobiotic receptor in inflammatory bowel disease.
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pubmed:affiliation |
Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Kentucky 40536, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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