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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1991-5-23
|
| pubmed:abstractText |
The hypothesis that chemically induced overt maternal toxicity induces a characteristic syndrome of adverse developmental effects in the rat was investigated. Pregnant animals (Sprague-Dawley strain) were dosed by oral gavage with one of a series of compounds on days 6-15 of gestation. These chemicals were diquat (DIQ), ethylene-bis-isothiocyanate (EBIS), toxaphene (TOX), styrene (STY), 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenol (2,4,5-Tr), triphenyl tin hydroxide (TPTH), and cacodylic acid (CAC). The compounds were chosen because they exhibited little or no developmental toxicity in previous studies. Dosage levels producing maternal weight loss and/or lethality were determined from preliminary toxicity studies. Significant maternal weight reductions were noted during the course of treatment with all compounds except CAC and 2,4,5-Tr. Maternal lethality was produced by EBIS, TOX, 2,4,-D, and 2,4,5-Tr. The main treatment-related developmental toxicity noted in litters at term consisted of increased lethality (EBIS, TPTH) and decreased fetal weight (EBIS and CAC). Treatment-related anomalies were seen in litters treated with 2,4-D and TOX (supernumerary ribs) and with EBIS and STY (enlarged renal pelvis). No significant developmental effects were produced with DIQ, or 2,4,5-Tr. This study indicates that overt maternal toxicity as defined by weight loss or mortality is not always associated with the same defined syndrome of adverse developmental effects in the rat.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4,5-Trichlorophenoxyacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/2,4-Dichlorophenoxyacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Cacodylic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Diquat,
http://linkedlifedata.com/resource/pubmed/chemical/Isothiocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/Organotin Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/Toxaphene,
http://linkedlifedata.com/resource/pubmed/chemical/triphenyltin hydroxide
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0040-3709
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
651-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2087686-2,4,5-Trichlorophenoxyacetic Acid,
pubmed-meshheading:2087686-2,4-Dichlorophenoxyacetic Acid,
pubmed-meshheading:2087686-Animals,
pubmed-meshheading:2087686-Body Weight,
pubmed-meshheading:2087686-Cacodylic Acid,
pubmed-meshheading:2087686-Diquat,
pubmed-meshheading:2087686-Embryonic and Fetal Development,
pubmed-meshheading:2087686-Female,
pubmed-meshheading:2087686-Fetal Death,
pubmed-meshheading:2087686-Fetal Diseases,
pubmed-meshheading:2087686-Isothiocyanates,
pubmed-meshheading:2087686-Maternal-Fetal Exchange,
pubmed-meshheading:2087686-Organotin Compounds,
pubmed-meshheading:2087686-Pregnancy,
pubmed-meshheading:2087686-Pregnancy Complications,
pubmed-meshheading:2087686-Rats,
pubmed-meshheading:2087686-Rats, Inbred Strains,
pubmed-meshheading:2087686-Stress, Physiological,
pubmed-meshheading:2087686-Thiocyanates,
pubmed-meshheading:2087686-Toxaphene
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Effects of chemically induced maternal toxicity on prenatal development in the rat.
|
| pubmed:affiliation |
Developmental Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
|
| pubmed:publicationType |
Journal Article
|