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rdf:type |
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lifeskim:mentions |
umls-concept:C0034693,
umls-concept:C0034837,
umls-concept:C0038836,
umls-concept:C0079411,
umls-concept:C0162362,
umls-concept:C0205216,
umls-concept:C0277785,
umls-concept:C0332281,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0521451,
umls-concept:C0751973
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-3
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pubmed:abstractText |
Impairments in mitochondrial function have been proposed to play a role in the etiology of diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in axons of sensory neurons in type 1 diabetes is due to abnormal activity of the respiratory chain and an altered mitochondrial proteome.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Methane,
http://linkedlifedata.com/resource/pubmed/chemical/Proteome,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquinone
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
288-97
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20876714-Animals,
pubmed-meshheading:20876714-Blood Glucose,
pubmed-meshheading:20876714-Body Weight,
pubmed-meshheading:20876714-Cells, Cultured,
pubmed-meshheading:20876714-Diabetes Mellitus, Experimental,
pubmed-meshheading:20876714-Drug Implants,
pubmed-meshheading:20876714-Hemoglobin A, Glycosylated,
pubmed-meshheading:20876714-Hypoglycemic Agents,
pubmed-meshheading:20876714-Insulin,
pubmed-meshheading:20876714-Male,
pubmed-meshheading:20876714-Methane,
pubmed-meshheading:20876714-Mitochondria,
pubmed-meshheading:20876714-Mitochondrial Membranes,
pubmed-meshheading:20876714-Neurons,
pubmed-meshheading:20876714-Oxidative Phosphorylation,
pubmed-meshheading:20876714-Oxygen Consumption,
pubmed-meshheading:20876714-Proteome,
pubmed-meshheading:20876714-Rats,
pubmed-meshheading:20876714-Rats, Sprague-Dawley,
pubmed-meshheading:20876714-Reactive Oxygen Species,
pubmed-meshheading:20876714-Sensory Receptor Cells,
pubmed-meshheading:20876714-Superoxides,
pubmed-meshheading:20876714-Ubiquinone
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pubmed:year |
2011
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pubmed:articleTitle |
Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats.
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pubmed:affiliation |
St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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