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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-21
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pubmed:abstractText |
Immunological disorders of the gastrointestinal tract such as inflammatory bowel disease often result in recurrent and persistently elevated levels of proinflammatory cytokines. Kinase suppressor of Ras 1 (KSR1) is involved in tumor necrosis factor-mediated colon epithelial cell survival, yet its role in chronic inflammation has not been defined. In this study, we tested the hypothesis that KSR1 is protective against spontaneous experimental colitis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011. Published by Elsevier Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-74
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pubmed:dateRevised |
2011-5-16
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pubmed:meshHeading |
pubmed-meshheading:20875416-Animals,
pubmed-meshheading:20875416-Antibodies, Neutralizing,
pubmed-meshheading:20875416-Bone Marrow Transplantation,
pubmed-meshheading:20875416-Cell Polarity,
pubmed-meshheading:20875416-Colitis,
pubmed-meshheading:20875416-Immunoglobulin G,
pubmed-meshheading:20875416-Interferon-gamma,
pubmed-meshheading:20875416-Interleukin-10,
pubmed-meshheading:20875416-Interleukin-17,
pubmed-meshheading:20875416-Mice,
pubmed-meshheading:20875416-Mice, Inbred BALB C,
pubmed-meshheading:20875416-Mucous Membrane,
pubmed-meshheading:20875416-Protein Kinases,
pubmed-meshheading:20875416-T-Lymphocytes,
pubmed-meshheading:20875416-Th1 Cells,
pubmed-meshheading:20875416-Th17 Cells
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pubmed:year |
2011
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pubmed:articleTitle |
KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-? production.
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pubmed:affiliation |
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine and Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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