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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-31
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pubmed:abstractText |
An important component of enteric inhibitory neurotransmission is mediated by a purine neurotransmitter, such as adenosine 5'-triphosphate (ATP), binding to P2Y1 receptors and activating small conductance K(+) channels. In murine colon ?-nicotinamide adenine dinucleotide (?-NAD) is released with ATP and mimics the pharmacology of inhibitory neurotransmission better than ATP. Here ?-NAD and ATP were compared as possible inhibitory neurotransmitters in human and monkey colons.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011. Published by Elsevier Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
608-617.e6
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pubmed:dateRevised |
2011-11-7
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pubmed:meshHeading |
pubmed-meshheading:20875415-Adenosine Triphosphate,
pubmed-meshheading:20875415-Adult,
pubmed-meshheading:20875415-Aged,
pubmed-meshheading:20875415-Animals,
pubmed-meshheading:20875415-Colon,
pubmed-meshheading:20875415-Electric Stimulation,
pubmed-meshheading:20875415-Enteric Nervous System,
pubmed-meshheading:20875415-Humans,
pubmed-meshheading:20875415-Ion Channels,
pubmed-meshheading:20875415-Macaca,
pubmed-meshheading:20875415-Male,
pubmed-meshheading:20875415-Membrane Potentials,
pubmed-meshheading:20875415-Middle Aged,
pubmed-meshheading:20875415-Muscle, Smooth,
pubmed-meshheading:20875415-NAD,
pubmed-meshheading:20875415-Neurotoxins,
pubmed-meshheading:20875415-Purinergic P2Y Receptor Antagonists,
pubmed-meshheading:20875415-Receptors, Purinergic P2Y,
pubmed-meshheading:20875415-Synaptic Transmission,
pubmed-meshheading:20875415-Tetrodotoxin,
pubmed-meshheading:20875415-omega-Conotoxin GVIA
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pubmed:year |
2011
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pubmed:articleTitle |
?-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.
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pubmed:affiliation |
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557-0352, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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