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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-12
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pubmed:abstractText |
Intestinal epithelial expression of antioxidants and nuclear factor kappa B (NF-?B) contribute to mucosal barrier integrity and epithelial homeostasis, two key events in the pathogenesis of inflammatory bowel disease (IBD). Genetic restoration of intestinal epithelial prohibitin 1 (PHB) levels during experimental colitis reduces the severity of disease through sustained epithelial antioxidant expression and reduced NF-?B activation. To determine the therapeutic potential of restoring epithelial PHB during experimental colitis in mice, we assessed two methods of PHB colonic mucosal delivery: adenovirus-directed administration by enema and poly(lactic acid) nanoparticle (NPs) delivery by gavage.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1536-4844
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1163-76
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20872832-Acute Disease,
pubmed-meshheading:20872832-Animals,
pubmed-meshheading:20872832-Caco-2 Cells,
pubmed-meshheading:20872832-Colitis,
pubmed-meshheading:20872832-Disease Models, Animal,
pubmed-meshheading:20872832-Drug Delivery Systems,
pubmed-meshheading:20872832-Green Fluorescent Proteins,
pubmed-meshheading:20872832-Humans,
pubmed-meshheading:20872832-Intestinal Mucosa,
pubmed-meshheading:20872832-Male,
pubmed-meshheading:20872832-Mice,
pubmed-meshheading:20872832-Mice, Inbred C57BL,
pubmed-meshheading:20872832-Mice, Mutant Strains,
pubmed-meshheading:20872832-NF-kappa B,
pubmed-meshheading:20872832-Nanoparticles,
pubmed-meshheading:20872832-Recombinant Fusion Proteins,
pubmed-meshheading:20872832-Repressor Proteins,
pubmed-meshheading:20872832-Tumor Necrosis Factor-alpha
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pubmed:year |
2011
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pubmed:articleTitle |
Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis.
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pubmed:affiliation |
Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA. atheiss@emory.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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