Source:http://linkedlifedata.com/resource/pubmed/id/20872152
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2010-10-25
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| pubmed:abstractText |
Vitamin D insufficiency is common in patients with chronic kidney disease (CKD) and may contribute to mineral bone disease. In a prospective interventional study, we estimated the prevalence of vitamin D insufficiency (serum 25-hydroxyvitamin D3 [25OHD] < 30 ng/ml), and examined the effect of high-dose (600,000 IU) cholecalciferol supplementation after 6 weeks on serum 25OHD and parathyroid hormone (PTH) levels in children with CKD stages 2-4. Forty-two children (86% boys) with a mean age of 7.7?±?3.8 (range 2--5) years were studied. Thirty-seven children (82.1%) had vitamin D insufficiency; 18 (42.8%) had 25OHD < 16 ng/ml. The median 25OHD increased significantly from 16.7 (95% CI 11.3, 19.8) to 46.2 (34.5, 44.6) ng/ml in patients with vitamin D insufficiency (P <0.001). The median PTH decreased significantly from 51.3 (95% CI 46.7, 71.5) to 37.1 (29.0, 54.6) pg/ml (P?=?0.003). Nineteen patients (47.5%) had >30% reduction in the PTH after supplementation. Serum calcium, phosphorus, and estimated GFR did not change significantly. We conclude that vitamin D insufficiency is highly prevalent in children with CKD stages 2-4. High-dose cholecalciferol is safe and effective in correcting vitamin D insufficiency and results in a significant reduction in PTH levels in vitamin D-insufficient children.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcifediol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholecalciferol,
http://linkedlifedata.com/resource/pubmed/chemical/PTH protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1432-198X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
25
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2483-8
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| pubmed:meshHeading |
pubmed-meshheading:20872152-Adolescent,
pubmed-meshheading:20872152-Biological Markers,
pubmed-meshheading:20872152-Calcifediol,
pubmed-meshheading:20872152-Child,
pubmed-meshheading:20872152-Child, Preschool,
pubmed-meshheading:20872152-Cholecalciferol,
pubmed-meshheading:20872152-Chronic Disease,
pubmed-meshheading:20872152-Female,
pubmed-meshheading:20872152-Humans,
pubmed-meshheading:20872152-Hyperparathyroidism, Secondary,
pubmed-meshheading:20872152-India,
pubmed-meshheading:20872152-Kidney Diseases,
pubmed-meshheading:20872152-Male,
pubmed-meshheading:20872152-Parathyroid Hormone,
pubmed-meshheading:20872152-Prevalence,
pubmed-meshheading:20872152-Prospective Studies,
pubmed-meshheading:20872152-Time Factors,
pubmed-meshheading:20872152-Treatment Outcome,
pubmed-meshheading:20872152-Vitamin D Deficiency,
pubmed-meshheading:20872152-Vitamins
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| pubmed:year |
2010
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| pubmed:articleTitle |
Vitamin D insufficiency and effect of cholecalciferol in children with chronic kidney disease.
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| pubmed:affiliation |
Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. pankajhari@hotmail.com
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| pubmed:publicationType |
Journal Article
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