Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-8
pubmed:abstractText
Inactivation of the p53 tumor suppressor pathway allows cell survival in times of stress and occurs in many human cancers; however, normal embryonic stem cells and some cancers such as neuroblastoma maintain wild-type human TP53 and mouse Trp53 (referred to collectively as p53 herein). Here we describe a miRNA, miR-380-5p, that represses p53 expression via a conserved sequence in the p53 3' untranslated region (UTR). miR-380-5p is highly expressed in mouse embryonic stem cells and neuroblastomas, and high expression correlates with poor outcome in neuroblastomas with neuroblastoma derived v-myc myelocytomatosis viral-related oncogene (MYCN) amplification. miR-380 overexpression cooperates with activated HRAS oncoprotein to transform primary cells, block oncogene-induced senescence and form tumors in mice. Conversely, inhibition of endogenous miR-380-5p in embryonic stem or neuroblastoma cells results in induction of p53, and extensive apoptotic cell death. In vivo delivery of a miR-380-5p antagonist decreases tumor size in an orthotopic mouse model of neuroblastoma. We demonstrate a new mechanism of p53 regulation in cancer and stem cells and uncover a potential therapeutic target for neuroblastoma.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/1R01CA136717, http://linkedlifedata.com/resource/pubmed/grant/5R01DC005991, http://linkedlifedata.com/resource/pubmed/grant/K08 CA104032-04, http://linkedlifedata.com/resource/pubmed/grant/K08 CA104032-05, http://linkedlifedata.com/resource/pubmed/grant/K08 NS048118-01A1, http://linkedlifedata.com/resource/pubmed/grant/K08 NS048118-02, http://linkedlifedata.com/resource/pubmed/grant/K08 NS048118-03, http://linkedlifedata.com/resource/pubmed/grant/K08 NS048118-04, http://linkedlifedata.com/resource/pubmed/grant/K08 NS048118-05, http://linkedlifedata.com/resource/pubmed/grant/K08 NS048118-06, http://linkedlifedata.com/resource/pubmed/grant/K08-CA104032, http://linkedlifedata.com/resource/pubmed/grant/K08NS48118, http://linkedlifedata.com/resource/pubmed/grant/P01 CA081403-11, http://linkedlifedata.com/resource/pubmed/grant/P01 CA081403-12, http://linkedlifedata.com/resource/pubmed/grant/P01CA081403, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08S1, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08S2, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08S3, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08S4, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08S5, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08S5S1, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-08S6, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-09, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-09S1, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-10, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-10S1, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-11, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-12, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-12S1, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-12S2, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-13, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-13S1, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-14, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-15, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-16, http://linkedlifedata.com/resource/pubmed/grant/P50 CA058207-17, http://linkedlifedata.com/resource/pubmed/grant/P50-CA58207, http://linkedlifedata.com/resource/pubmed/grant/R01 CA102321-04A1, http://linkedlifedata.com/resource/pubmed/grant/R01 CA102321-05, http://linkedlifedata.com/resource/pubmed/grant/R01 CA102321-06, http://linkedlifedata.com/resource/pubmed/grant/R01 CA102321-07, http://linkedlifedata.com/resource/pubmed/grant/R01 CA102321-08, http://linkedlifedata.com/resource/pubmed/grant/R01 CA136717-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 CA136717-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DC005991-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 DC005991-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DC005991-02S1, http://linkedlifedata.com/resource/pubmed/grant/R01 DC005991-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DC005991-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DC005991-05, http://linkedlifedata.com/resource/pubmed/grant/R01 DC005991-05S1, http://linkedlifedata.com/resource/pubmed/grant/R01 NS055750-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 NS055750-01A2S1, http://linkedlifedata.com/resource/pubmed/grant/R01 NS055750-02, http://linkedlifedata.com/resource/pubmed/grant/R01 NS055750-02S1, http://linkedlifedata.com/resource/pubmed/grant/R01 NS055750-03, http://linkedlifedata.com/resource/pubmed/grant/R01 NS055750-04, http://linkedlifedata.com/resource/pubmed/grant/R01 NS055750-05, http://linkedlifedata.com/resource/pubmed/grant/R01CA102321, http://linkedlifedata.com/resource/pubmed/grant/R01NS055750
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-8183575, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-9214616, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-9135153, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-10597243, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-10783169, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-11196202, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-12438652, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-12567186, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-12821781, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-12824337, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-12880966, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-14709173, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-15286780, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-15310658, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-15738393, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-15951802, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-16540699, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-16557269, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-16557279, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-16575006, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-16912192, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-17110380, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-17182091, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-17251932, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-17251933, http://linkedlifedata.com/resource/pubmed/commentcorrection/20871609-17322916
More...