Source:http://linkedlifedata.com/resource/pubmed/id/20870446
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2010-12-6
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| pubmed:abstractText |
The objective of this study was to identify possible group differences between PD patients with dementia and without dementia by combining different functional and structural imaging methods in vivo, which might provide an opportunity to disentangle the pathophysiological correlates of cognitive impairment and dementia in PD. We performed a neuropsychological evaluation, structural brain MRI, [(18)F]FDG PET and [(11)C]PIB PET in 19 PD patients [eight non-demented (PD), eleven demented (PDD)] and 24 healthy elderly volunteers. [(11)C]PIB region-to-cerebellum ratios did not differ significantly between the groups in any brain region (p > 0.05). PDD patients showed impaired glucose metabolism in cortical brain regions and this reduction was associated with the degree of cognitive impairment. PDD patients had more atrophy both in the hippocampus and the frontal cortex compared with PD patients and controls, and hippocampal atrophy was associated with impaired memory. This cross-sectional data suggests that development of dementia in PD is associated with extensive spread of hypometabolism beyond the occipital cortex, and with hippocampal and frontal atrophy but not beta-amyloid deposition consistent with a unique biological process related to PD rather than co-incidental development of AD in persons with PD.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzothiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorodeoxyglucose F18,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/N-methyl-2-(4'-methylaminophenyl)-6-...,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1873-5126
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
666-70
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| pubmed:meshHeading |
pubmed-meshheading:20870446-Aged,
pubmed-meshheading:20870446-Aged, 80 and over,
pubmed-meshheading:20870446-Atrophy,
pubmed-meshheading:20870446-Benzothiazoles,
pubmed-meshheading:20870446-Cerebellum,
pubmed-meshheading:20870446-Dementia,
pubmed-meshheading:20870446-Female,
pubmed-meshheading:20870446-Fluorodeoxyglucose F18,
pubmed-meshheading:20870446-Frontal Lobe,
pubmed-meshheading:20870446-Glucose,
pubmed-meshheading:20870446-Hippocampus,
pubmed-meshheading:20870446-Humans,
pubmed-meshheading:20870446-Magnetic Resonance Imaging,
pubmed-meshheading:20870446-Male,
pubmed-meshheading:20870446-Middle Aged,
pubmed-meshheading:20870446-Neuropsychological Tests,
pubmed-meshheading:20870446-Parkinson Disease,
pubmed-meshheading:20870446-Positron-Emission Tomography,
pubmed-meshheading:20870446-Radiopharmaceuticals
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| pubmed:year |
2010
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| pubmed:articleTitle |
[(11)C]PIB-, [(18)F]FDG-PET and MRI imaging in patients with Parkinson's disease with and without dementia.
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| pubmed:affiliation |
Turku PET Centre, Turku University Hospital, 20520 Turku, Finland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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