Linked Life Data

20870327

Source:http://linkedlifedata.com/resource/pubmed/id/20870327

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-10-25
pubmed:abstractText
Plasma cell dyscrasias can present as myeloma cast nephropathy, AL amyloid, or light chain deposition disease. We describe the unusual kidney biopsy findings of concurrent myeloma cast nephropathy and glomerular nonamyloid fibrillary deposits composed of immunoglobulin G (IgG) heavy chains and ? light chains in a patient with multiple myeloma who presented with acute renal failure. We performed laser microdissection and mass spectrometry-based proteomic analysis, which showed that the fibrillary deposits likely contained Ig?1 constant region and ? light chain constant region, whereas ? light chains and serum amyloid P proteins were absent. Treatment of multiple myeloma resulted in resolution of the renal manifestations, suggesting a common underlying mechanism for the cast nephropathy and heavy and light chain deposition disease. We show that laser microdissection and mass spectrometry is an extremely useful ancillary test for the diagnosis of heavy and light chain deposition diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1523-6838
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
971-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Coexistence of myeloma cast nephropathy, light chain deposition disease, and nonamyloid fibrils in a patient with multiple myeloma.
pubmed:affiliation
Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55902, USA.
pubmed:publicationType
Journal Article, Case Reports