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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-29
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pubmed:abstractText |
Clozapine is considered to be the most efficacious drug to treat schizophrenia, although it is underutilized, partially due to a side effect of agranulocytosis. This analysis of 74 candidate genes was designed to identify an association between sequence variants and clozapine-induced agranulocytosis (CIA).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1555-2101
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pubmed:author |
pubmed-author:AthanasiouMaria CMC,
pubmed-author:CascorbiIngolfI,
pubmed-author:DettlingMichaelM,
pubmed-author:FryJ LJL,
pubmed-author:GersonStanton LSL,
pubmed-author:KaneJohn MJM,
pubmed-author:LenczToddT,
pubmed-author:MalhotraAnil KAK,
pubmed-author:MosyaginIgorI,
pubmed-author:PierzKerri AKA,
pubmed-author:ReedCarol RCR,
pubmed-author:SalisburyBenjamin ABA,
pubmed-author:WhalenHeidiH
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pubmed:copyrightInfo |
© Copyright 2011 Physicians Postgraduate Press, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
458-63
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20868635-Adult,
pubmed-meshheading:20868635-Agranulocytosis,
pubmed-meshheading:20868635-Antipsychotic Agents,
pubmed-meshheading:20868635-Case-Control Studies,
pubmed-meshheading:20868635-Clozapine,
pubmed-meshheading:20868635-Female,
pubmed-meshheading:20868635-Genetic Association Studies,
pubmed-meshheading:20868635-Genetic Predisposition to Disease,
pubmed-meshheading:20868635-Genotype,
pubmed-meshheading:20868635-HLA-DQ Antigens,
pubmed-meshheading:20868635-HLA-DQ beta-Chains,
pubmed-meshheading:20868635-Humans,
pubmed-meshheading:20868635-Male,
pubmed-meshheading:20868635-Middle Aged,
pubmed-meshheading:20868635-Polymorphism, Single Nucleotide,
pubmed-meshheading:20868635-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis.
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pubmed:affiliation |
PGxHealth, 5 Science Park, New Haven, CT 06511, USA. mathanasiou@pgxhealth.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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