Linked Life Data

20865634

Source:http://linkedlifedata.com/resource/pubmed/id/20865634

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-9-24
pubmed:abstractText
The typical form of hemolytic uremic syndrome (HUS) is associated with enterohemorrhagic ESCHERICHIA COLI (EHEC) infection. The disease process is initiated and perpetuated by interactions between the pathogen or its virulence factors and host cells, as well as the host response. During EHEC-associated HUS, alterations occurring at the intestinal mucosal barrier and in the circulation, as well as on endothelial cells and other target-organ cells, lead to cell activation and/or cytotoxicity, and trigger a prothrombotic state. This review summarizes current knowledge regarding the interactions of the pathogen and its virulence factors with cells in the intestine, bloodstream, kidney, and brain. Mechanisms of bacterial colonization, toxin circulation, and induction of target organ damage are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1098-9064
pubmed:author
pubmed:copyrightInfo
© Thieme Medical Publishers.
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
575-85
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Pathophysiology of typical hemolytic uremic syndrome.
pubmed:affiliation
Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden. diana.karpman@med.lu.se
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't