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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-5-20
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pubmed:abstractText |
The methylation of membrane phospholipids has been shown to occur following receptor-mediated activation of leukocytes. The present studies show that the human lymphocyte response to two positive chemokinetic signals (bradykinin and lymphocyte chemoattractant factor) can be interrupted by inhibitors of S-adenosyl-L-methionine-mediated transmethylation reactions. The chemokinetic response to the nonphysiologic stimulant colchicine is not affected. We speculate that phospholipid methylation accompanies receptor-mediated lymphocyte migration, and may facilitate activation of second messenger systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/9-(2-hydroxy-3-nonyl)adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Deaminase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Colchicine,
http://linkedlifedata.com/resource/pubmed/chemical/Homocysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-16,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/S-Adenosylmethionine,
http://linkedlifedata.com/resource/pubmed/chemical/homocysteine thiolactone
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0165-2478
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2086448-Adenine,
pubmed-meshheading:2086448-Adenosine Deaminase Inhibitors,
pubmed-meshheading:2086448-Animals,
pubmed-meshheading:2086448-Bradykinin,
pubmed-meshheading:2086448-Chemotaxis, Leukocyte,
pubmed-meshheading:2086448-Colchicine,
pubmed-meshheading:2086448-Homocysteine,
pubmed-meshheading:2086448-Humans,
pubmed-meshheading:2086448-Interleukin-16,
pubmed-meshheading:2086448-Leukocytes, Mononuclear,
pubmed-meshheading:2086448-Lymphocytes,
pubmed-meshheading:2086448-Lymphokines,
pubmed-meshheading:2086448-Male,
pubmed-meshheading:2086448-Membrane Lipids,
pubmed-meshheading:2086448-Methylation,
pubmed-meshheading:2086448-Phospholipids,
pubmed-meshheading:2086448-Rats,
pubmed-meshheading:2086448-Rats, Inbred Strains,
pubmed-meshheading:2086448-S-Adenosylmethionine,
pubmed-meshheading:2086448-Second Messenger Systems
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pubmed:year |
1990
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pubmed:articleTitle |
Inhibitors of membrane transmethylation reactions prevent the lymphocyte chemokinetic response.
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pubmed:affiliation |
Department of Medicine, Lawson Research Institute of St. Joseph's Health Centre, London, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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