rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-25
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pubmed:abstractText |
Surgical treatment for lumbar degenerative disc disease (DDD) has been associated with highly variable results in terms of postoperative pain relief and functional improvement. Many experts believe that DDD should be considered a chronic pain disorder as opposed to a degenerative disease. Genetic variation of the catechol-O-methyltransferase (COMT) gene has been associated with variation in human pain sensitivity and response to analgesics in previous studies.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1878-1632
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pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
949-57
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20863768-Adult,
pubmed-meshheading:20863768-Catechol O-Methyltransferase,
pubmed-meshheading:20863768-Disability Evaluation,
pubmed-meshheading:20863768-Female,
pubmed-meshheading:20863768-Humans,
pubmed-meshheading:20863768-Intervertebral Disc Degeneration,
pubmed-meshheading:20863768-Low Back Pain,
pubmed-meshheading:20863768-Lumbar Vertebrae,
pubmed-meshheading:20863768-Male,
pubmed-meshheading:20863768-Middle Aged,
pubmed-meshheading:20863768-Pain Measurement,
pubmed-meshheading:20863768-Pilot Projects,
pubmed-meshheading:20863768-Polymorphism, Single Nucleotide,
pubmed-meshheading:20863768-Recovery of Function,
pubmed-meshheading:20863768-Spinal Fusion,
pubmed-meshheading:20863768-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.
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pubmed:affiliation |
Molecular Epidemiology of Pain Program, Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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