Linked Life Data

20863736

Source:http://linkedlifedata.com/resource/pubmed/id/20863736

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-12-14
pubmed:abstractText
Interferon regulatory factors (IRFs) were first identified during studies of type I interferons. Since then, many investigations have established that IRFs are involved in regulating the innate immune response, the development of various immune cell types, and carcinogenesis. Several genetic studies have identified genetic variants, most notably IRF5, associated with an increased risk of autoimmune disease. The biological role for IRFs in autoimmune diseases has been evaluated not only in vitro, but also in vivo in various murine models. Here, we discuss the role for the various IRFs, particularly in toll-like receptor signaling pathways. We also review the evidence supporting a role for IRFs in dysimmune diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1778-7254
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
525-31
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Role for interferon regulatory factors in autoimmunity.
pubmed:affiliation
CNRS UMR 5164, université Bordeaux 2, 146, rue Léo-Saignat, 33076 Bordeaux, France. christophe.richez@chu-bordeaux.fr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't