Source:http://linkedlifedata.com/resource/pubmed/id/20863734
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-11-8
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| pubmed:abstractText |
BACKGROUND: Hospital-associated pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. Many aspects of the treatment of HAP caused by multi-resistant Gram-positive microorganisms have been extensively studied, but controversial issues remain. CONTROVERSIAL ISSUES: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group - a panel of multidisciplinary experts - was to define recommendations for some controversial issues using an evidence-based and analytical approach. The controversial issues were: (1) Is combination antibiotic therapy or monotherapy more effective in the treatment of HAP? (2) What role do pharmacokinetic/pharmacodynamic antibiotic features have as a guide in the selection of treatment for HAP? (3) Is a de-escalation approach for the management of HAP effective? An analysis of the studies published up until April 2009 is presented and discussed in detail. METHODS: A systematic literature search using PubMed, MEDLINE, and EMBASE databases and the Cochrane Library was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle-Ottawa Quality Assessment Scale for case-control studies, longitudinal cohorts, and retrospective studies. The GRADE method for grading quality of evidence was applied.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1878-3511
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| pubmed:author |
pubmed-author:AntonelliMassimoM,
pubmed-author:BassettiMatteoM,
pubmed-author:BlasiFrancescoF,
pubmed-author:CarosiGiampieroG,
pubmed-author:FranzettiFabioF,
pubmed-author:GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) Working Group...,
pubmed-author:IppolitoGiuseppeG,
pubmed-author:LangerMartinM,
pubmed-author:LauriaFrancesco NFN,
pubmed-author:MoroniMauroM,
pubmed-author:NicastriEmanueleE,
pubmed-author:ScaglioneFrancescoF
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| pubmed:copyrightInfo |
Copyright © 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
14 Suppl 4
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S55-65
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| pubmed:meshHeading |
pubmed-meshheading:20863734-Anti-Bacterial Agents,
pubmed-meshheading:20863734-Cross Infection,
pubmed-meshheading:20863734-Drug Therapy, Combination,
pubmed-meshheading:20863734-Evidence-Based Medicine,
pubmed-meshheading:20863734-Gram-Positive Bacteria,
pubmed-meshheading:20863734-Gram-Positive Bacterial Infections,
pubmed-meshheading:20863734-Humans,
pubmed-meshheading:20863734-Pneumonia, Bacterial,
pubmed-meshheading:20863734-Randomized Controlled Trials as Topic,
pubmed-meshheading:20863734-Treatment Outcome
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| pubmed:year |
2010
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| pubmed:articleTitle |
Consensus document on controversial issues for the treatment of hospital-associated pneumonia.
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| pubmed:affiliation |
Clinica Universitaria di Malattie Infettive e Tropicali, Azienda Ospedaliera Universitaria Luigi Sacco, Università degli Studi di Milano, Milano, Italy. fabio.franzetti@unimi.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Consensus Development Conference
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