Linked Life Data

20863313

Source:http://linkedlifedata.com/resource/pubmed/id/20863313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-9-24
pubmed:abstractText
HSs (heparan sulfates) are a complex family of cell-surface and matrix polysaccharides that have diverse biological functions, underpinned by structurally diverse patterns of backbone chain modification, especially by sulfate groups. These variant structures represent a molecular code, the 'heparanome', that confers the ability to interact selectively with a wide interactome of proteins, the 'heparactome', and thereby influence a network of cellular events. It is becoming increasingly apparent that understanding the structure-activity relationships of these enigmatic molecules requires the development of a holistic systems biology view of their structure and interactions. In the present paper, I describe some of the new tools available to realize this strategy, and discuss the future potential for the combined application of glycomics and other '-omics' approaches to define the molecular code of the heparanome.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1470-8752
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1356-60
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Heparan sulfate glycomics: towards systems biology strategies.
pubmed:affiliation
Centre for Glycobiology, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK. j.turnbull@liverpool.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't