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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-10-20
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pubmed:abstractText |
In a whole-genome scan, a single nucleotide polymorphism (SNP) (rs7566605) upstream of the insulin-induced gene 2 (INSIG2) was shown to influence body mass index and obesity in the Framingham Heart Study, with replication of these results in an additional 4 of 5 studies. However, other studies could not replicate the association. Because INSIG2 plays an important role in cholesterol biosynthesis, we hypothesized that human INSIG2 variants might play a role in the regulation of plasma lipid and lipoprotein levels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1942-3268
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pubmed:author |
pubmed-author:AnandSoniaS,
pubmed-author:BaileySwneke DSD,
pubmed-author:BouchardClaudeC,
pubmed-author:DesbiensKatiaK,
pubmed-author:DoRonR,
pubmed-author:EngertJames CJC,
pubmed-author:GaudetDanielD,
pubmed-author:HudsonThomas JTJ,
pubmed-author:MontpetitAlexandreA,
pubmed-author:PérusseLouisL,
pubmed-author:ParéGuillaumeG,
pubmed-author:PastinenTomiT,
pubmed-author:VohlMarie-ClaudeMC,
pubmed-author:YusufSalimS
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
454-61
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pubmed:dateRevised |
2011-8-4
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pubmed:meshHeading |
pubmed-meshheading:20858904-Adult,
pubmed-meshheading:20858904-Animals,
pubmed-meshheading:20858904-Apolipoproteins B,
pubmed-meshheading:20858904-Cholesterol, LDL,
pubmed-meshheading:20858904-Chromosome Mapping,
pubmed-meshheading:20858904-Genome-Wide Association Study,
pubmed-meshheading:20858904-Genotype,
pubmed-meshheading:20858904-Humans,
pubmed-meshheading:20858904-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20858904-Membrane Proteins,
pubmed-meshheading:20858904-Microfilament Proteins,
pubmed-meshheading:20858904-Middle Aged,
pubmed-meshheading:20858904-Obesity,
pubmed-meshheading:20858904-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels.
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pubmed:affiliation |
Department of Human Genetics, McGill University, Montreal, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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