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rdf:type |
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lifeskim:mentions |
umls-concept:C0015252,
umls-concept:C0140278,
umls-concept:C0333562,
umls-concept:C0596508,
umls-concept:C0719517,
umls-concept:C0728940,
umls-concept:C1366536,
umls-concept:C1415408,
umls-concept:C1425420,
umls-concept:C1514873,
umls-concept:C1539902,
umls-concept:C1546857,
umls-concept:C1549879,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1705627,
umls-concept:C2349182
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pubmed:issue |
2
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pubmed:dateCreated |
2010-11-30
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pubmed:abstractText |
Retinoic acid (RA) induces embryonic stem cell differentiation. The effects of RA are mediated by retinoic acid receptors (RARs) that promote epigenetic changes controlling gene transcription. We show here that RAR?, in the absence of the ligand RA, is required for deposition of the histone variant H2A.Z and the polycomb group protein Suz12 at RA target genes, and that in embryonic stem cells both RAR? and Suz12 exist in a multi-protein complex in the absence of ligand. Addition of RA causes removal of H2A.Z and Suz12 from RAR? target genes when the genes are transcriptionally activated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CEBPA protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Suz12 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/histone H2A.F-Z,
http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid 4-hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor gamma
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-4652
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
226
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
293-8
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pubmed:dateRevised |
2011-4-11
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pubmed:meshHeading |
pubmed-meshheading:20857416-Animals,
pubmed-meshheading:20857416-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:20857416-Cell Differentiation,
pubmed-meshheading:20857416-Cells, Cultured,
pubmed-meshheading:20857416-Cytochrome P-450 Enzyme System,
pubmed-meshheading:20857416-Embryonic Stem Cells,
pubmed-meshheading:20857416-Epigenesis, Genetic,
pubmed-meshheading:20857416-Gene Expression Regulation,
pubmed-meshheading:20857416-Histones,
pubmed-meshheading:20857416-Mice,
pubmed-meshheading:20857416-Mice, Knockout,
pubmed-meshheading:20857416-Promoter Regions, Genetic,
pubmed-meshheading:20857416-Receptors, Retinoic Acid,
pubmed-meshheading:20857416-Repressor Proteins,
pubmed-meshheading:20857416-Tretinoin
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pubmed:year |
2011
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pubmed:articleTitle |
RAR? is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.
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pubmed:affiliation |
Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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