Linked Life Data

20857232

Source:http://linkedlifedata.com/resource/pubmed/id/20857232

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-2-25
pubmed:abstractText
Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. Previous studies have shown alterations in the central cholinergic neurotransmission after TBI. We therefore determined ?7 nicotinic acetylcholine receptor (nAChR) densities in newborn piglets and adult rats after experimental TBI. Thirteen newborn piglets (post-TBI survival time: 6 h) underwent fluid percussion (FP) injury (n = 7) or sham operation (n = 6). Furthermore, adult rats randomized into three groups of post-TBI survival times (2, 24, 72 h) received controlled cortical impact injury (CCI, n = 8) or sham operation (n = 8). Brains were frozen, sagittally cut and incubated with the ?7-specific radioligand [(125)I]?-bungarotoxin for autoradiography. In injured newborn piglets, decreased ?7 receptor densities were observed in the hippocampus (-38%), the hippocampus CA1 (-40%), thalamus (-30%) and colliculus superior (-30%). In adult rats, CCI decreased the receptor densities (between -16 and -47%) in almost any brain region within 2 and 24 h. In conclusion, widespread and significantly lowered ?7 nAChR densities were demonstrated in both TBI models. Our results suggest that a nearly similar TBI-induced decrease in the ?7 density in the brain of immature and adult animals is found, even with the differences in species, age and experimental procedures. The alterations make the ?7 nAChR a suitable target for drug development and neuroimaging after TBI.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1559-1174
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
44-53
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Traumatic brain injury elicits similar alterations in ?7 nicotinic receptor density in two different experimental models.
pubmed:affiliation
Institute of Radiopharmacy, Research Site Leipzig, Research Center Dresden-Rossendorf, Permoserstraße 15, 04318, Leipzig, Germany.
pubmed:publicationType
Journal Article