20856158

Source:http://linkedlifedata.com/resource/pubmed/id/20856158

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0027859, umls-concept:C0038952, umls-concept:C0596290, umls-concept:C1514559, umls-concept:C1880177
pubmed:issue	9
pubmed:dateCreated	2010-11-11
pubmed:abstractText	Elevated levels of hsa-microRNA-21 (miR-21) in vestibular schwannomas (VSs) may contribute to tumor growth by downregulating the tumor suppressor phosphatase and tensin homolog (PTEN) and consequent hyperactivation of protein kinase B (AKT), a key signaling protein in the cellular pathways that lead to tumor growth.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/K08 DC006211-05, http://linkedlifedata.com/resource/pubmed/grant/K08DC006211, http://linkedlifedata.com/resource/pubmed/grant/R01 DC009801-03, http://linkedlifedata.com/resource/pubmed/grant/R01DC02971
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100961504
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/MIRN21 microRNA, human, http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs, http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase, http://linkedlifedata.com/resource/pubmed/chemical/PTEN protein, human, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	1537-4505
pubmed:author	pubmed-author:CioffiJoseph AJA, pubmed-author:HansenKameron RKR, pubmed-author:HansenMarlan RMR, pubmed-author:Mendolia-LoffredoSabrinaS, pubmed-author:WackymP AshleyPA, pubmed-author:YueWei YingWY
pubmed:issnType	Electronic
pubmed:volume	31
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1455-62
pubmed:dateRevised	2011-6-2
pubmed:meshHeading	pubmed-meshheading:20856158-Apoptosis, pubmed-meshheading:20856158-Blotting, Western, pubmed-meshheading:20856158-Cell Proliferation, pubmed-meshheading:20856158-Cell Survival, pubmed-meshheading:20856158-Cells, Cultured, pubmed-meshheading:20856158-Cranial Nerve Neoplasms, pubmed-meshheading:20856158-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:20856158-Gene Knockdown Techniques, pubmed-meshheading:20856158-Humans, pubmed-meshheading:20856158-Immunohistochemistry, pubmed-meshheading:20856158-MicroRNAs, pubmed-meshheading:20856158-Neurofibromatosis 2, pubmed-meshheading:20856158-Neuroma, Acoustic, pubmed-meshheading:20856158-PTEN Phosphohydrolase, pubmed-meshheading:20856158-RNA, Messenger, pubmed-meshheading:20856158-RNA, Neoplasm, pubmed-meshheading:20856158-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:20856158-Transfection, pubmed-meshheading:20856158-Vestibulocochlear Nerve
pubmed:year	2010
pubmed:articleTitle	MicroRNA-21 overexpression contributes to vestibular schwannoma cell proliferation and survival.
pubmed:affiliation	Legacy Clinical Research and Technology Center, Portland, Oregon 97232, USA. joeciof@aol.com
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural