Linked Life Data

20854131

Source:http://linkedlifedata.com/resource/pubmed/id/20854131

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-14
pubmed:abstractText
Tumor necrosis factor alpha (TNF-?) is thought to be involved in the pathogenic and metabolic events associated with HIV-1 infection. We assessed whether carriage of the TNF-? gene promoter single nucleotide polymorphism (SNP) is associated with lipodystrophy and metabolic derangements in HIV-1-infected patients treated with cART. We also assessed variations in TNF-? receptor plasma levels. The study group comprised 286 HIV-1-infected patients (133 with and 153 without lipodystrophy) and 203 uninfected controls (UC). TNF-? -238G?>?A, -308G?>?A, and -863 C?>?A SNP were assessed using PCR-RFLPs on white cell DNA. Plasma sTNF-? R1 and R2 levels were measured by ELISA. Student's t test, the ?(2) test, Pearson correlations, and the logistic regression test were performed for statistical analysis. The TNF-? -308G?>?A SNP was significantly associated with lipodystrophy in the univariate analysis (p = 0.04). This association, however, was no longer significant in the multivariate analysis. A meta-analysis of the published literature and our own data, which included 284 patients with lipodystrophy and 338 without lipodystrophy, showed that there was no relationship between the TNF-? -238G?>?A and -308G?>?A SNP and lipodystrophy (p?>?0.05 for all comparisons). HIV-1-infected patients had greater sTNF-? R2 plasma levels than UC (p = 0.001) whereas sTNF-? R1 and R2 levels were not significantly different in both the HIV-1-infected cohorts, lipodystrophy vs. nonlipodystrophy (p = NS). In our cohort of white Spaniards the TNF-? -238G?>?A, -308G?>?A, and -863C?>?A SNP were not associated with lipodystrophy in HIV-1-infected patients treated with cART. This finding was replicated in a meta-analysis of the published data, which showed no associations between the TNF-? -238G?>?A and -308G?>?A SNP and lipodystrophy. In HIV-1-infected patients under cART there is a systemic overproduction of sTNF-? R2, which is unrelated to the presence of lipodystrophy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1931-8405
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-52
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
No relationship between TNF-? genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV type 1-infected patients: a case-control study and a meta-analysis.
pubmed:affiliation
Hospital Universitari de Tarragona Joan XXIII, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study, Meta-Analysis