Linked Life Data

20853421

Source:http://linkedlifedata.com/resource/pubmed/id/20853421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-17
pubmed:abstractText
A major, and sometimes heated, debate in evolutionary and developmental biology is about the genetic basis of morphological evolution and the molecular mechanisms of gene regulatory evolution. Central to this argument is whether gene regulation most often evolves from changes in the cis-regulatory elements of genes or through changes in the transcription factors that bind to regulatory elements. Although various kinds of theoretical and experimental evidence have been used to advance the cause of both sides, none has been more influential than the finding that transcription factors from very different organisms can be functionally conserved. In this perspective, we review the now classic finding that Pax6 genes from flies and vertebrates are functionally conserved in eye development and can induce the formation of eyes when swapped between species. While a conserved role for Pax6 genes in eye development is undebatable, we show that evidence of divergent Pax6 functions has been overlooked and propose that Pax6 genes have evolved novel protein functions during the development of the Drosophila eye, coincident with the evolution of a novel eye developmental mechanism in cyclorrhaphan dipterans. Thus, we conclude that Pax6 genes are both functionally equivalent and divergent between species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1552-5015
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Wiley-Liss, Inc., A Wiley Company.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
316B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Revisiting a classic example of transcription factor functional equivalence: are Eyeless and Pax6 functionally equivalent or divergent?
pubmed:affiliation
Department of Ecology and Evolutionary Biology and Yale Institute for Systems Biology, Yale University, New Haven, Connecticut 06511, USA. vincent.j.lynch@yale.edu
pubmed:publicationType
Editorial, Research Support, Non-U.S. Gov't