Source:http://linkedlifedata.com/resource/pubmed/id/20852882
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-1-12
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| pubmed:abstractText |
Short-term leg immobilization is an acute model of inactivity, which induces vascular deconditioning. The present study was conducted to determine if short-term leg immobilization induced alterations in central and peripheral conduit artery structure (diameter and compliance), function (resting blood flow and mean wall shear rate), and peripheral flow-mediated dilation. Healthy participants (n = 7 women and n = 8 men) were studied before and after 12 days of unilateral leg immobilization. Carotid artery structure and function were unaltered with immobilization indicating that the unilateral immobilization did not have a detectable effect on this representative central artery. In contrast, peripheral measures of arterial structure at the common femoral and popliteal arteries showed significant reductions in both the immobilized and non-immobilized limbs but to a greater extent in the immobilized limbs. Specifically, femoral and popliteal artery compliance and femoral artery diameter were reduced in both the immobilized and the non-immobilized limb (p < 0.05) while popliteal artery diameter was reduced only in the immobilized leg. Popliteal artery flow-mediated dilation, an indicator of peripheral artery function, was increased in the immobilized limb, which parallels reports in paralyzed limbs of spinal-cord-injured individuals. The time course of vascular alterations with inactivity likely follows a sequence of adaptations in arterial structure and function reflecting differing initial flow patterns, and arterial wall composition, and diverse hemodynamic stimuli within different blood vessels.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1439-6327
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
111
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
203-10
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| pubmed:meshHeading |
pubmed-meshheading:20852882-Adult,
pubmed-meshheading:20852882-Blood Flow Velocity,
pubmed-meshheading:20852882-Blood Pressure,
pubmed-meshheading:20852882-Female,
pubmed-meshheading:20852882-Femoral Artery,
pubmed-meshheading:20852882-Heart Rate,
pubmed-meshheading:20852882-Hemodynamics,
pubmed-meshheading:20852882-Humans,
pubmed-meshheading:20852882-Immobilization,
pubmed-meshheading:20852882-Leg,
pubmed-meshheading:20852882-Male,
pubmed-meshheading:20852882-Organ Size,
pubmed-meshheading:20852882-Popliteal Artery,
pubmed-meshheading:20852882-Regional Blood Flow,
pubmed-meshheading:20852882-Rest,
pubmed-meshheading:20852882-Time Factors,
pubmed-meshheading:20852882-Vascular Resistance,
pubmed-meshheading:20852882-Young Adult
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans.
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| pubmed:affiliation |
Department of Kinesiology, McMaster University, Hamilton, ON, Canada. m.e.rakobowchuk@leeds.ac.uk
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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