Linked Life Data

20852128

Source:http://linkedlifedata.com/resource/pubmed/id/20852128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
2010-12-17
pubmed:abstractText
Human ?? T-cell lymphoma is a rare clinicopathologic entity with aggressive course and poor prognosis. The etiology and pathogenesis of ?? T-cell lymphoma is unknown. We show here that mice with deficiency in inhibitory helix-loop-helix protein Id3 (Id3(-/-)) developed ?? T-cell lymphoma that resembled human ?? T-cell lymphoma. The Id3(-/-) mice with lymphoma showed splenomegaly, hepatomegaly, and lymphadenopathy with involvement of bone marrow, thymus, kidney, and lungs between 6 and 15 months of age. Phenotypic analysis revealed that lymphomatous cells were cluster of differentiation (CD)3(+), ?? T-cell receptor (TCR)(+), and ?? TCR(-), and expressed CD8(+)CD4(-), CD4(+)CD8(-), or a mixture of the two. Id3(-/-) ?? T-cell lymphoma used predominantly V?1.1, some V?3, yet no V?2 TCR, and some showed increased levels of the oncogene c-Myc. Strikingly, adoptive transfer of the ?? T-cell lymphoma into syngeneic Rag1(-/-) mice resulted in aggressive ?? T-cell lymphoma, identical to the Id3(-/-) donor. Thus, our data demonstrate that Id3 regulates the development of ?? T-cell lymphoma in mice, raising a possibility of Id3 gene mutation in human ?? T-cell lymphoma. Our model will provide a tool for studying the molecular mechanisms and development of human ?? T-cell lymphoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5615-21
pubmed:dateRevised
2011-3-4
pubmed:meshHeading
pubmed-meshheading:20852128-Adoptive Transfer, pubmed-meshheading:20852128-Animals, pubmed-meshheading:20852128-Blotting, Western, pubmed-meshheading:20852128-Cell Differentiation, pubmed-meshheading:20852128-Flow Cytometry, pubmed-meshheading:20852128-Homeodomain Proteins, pubmed-meshheading:20852128-Humans, pubmed-meshheading:20852128-Immunoenzyme Techniques, pubmed-meshheading:20852128-Inhibitor of Differentiation Proteins, pubmed-meshheading:20852128-Lymphoma, T-Cell, pubmed-meshheading:20852128-Mice, pubmed-meshheading:20852128-Mice, Inbred C57BL, pubmed-meshheading:20852128-Mice, Knockout, pubmed-meshheading:20852128-Mutation, pubmed-meshheading:20852128-RNA, Messenger, pubmed-meshheading:20852128-Receptors, Antigen, T-Cell, gamma-delta, pubmed-meshheading:20852128-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2010
pubmed:articleTitle
Mutation of inhibitory helix-loop-helix protein Id3 causes ?? T-cell lymphoma in mice.
pubmed:affiliation
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Intramural