Source:http://linkedlifedata.com/resource/pubmed/id/20851747
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-11-8
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| pubmed:abstractText |
Previous studies have demonstrated the involvement of astrocytes in the modulation of pain. The water channel aquaporin-4, which is expressed in astrocytes but not neurons, has also been demonstrated to function in sensory processing, including hearing, vision, and olfaction. In the present study, we investigated a possible role of aquaporin-4 in the processing of nociception by measuring behavioral responses to noxious stimulation in aquaporin-4 knockout mice. Pain thresholds were increased in knockout mice, when compared to wild-type mice, with thermal and chemical stimulation but not mechanical stimulation. Aquaporin-4 knockout mice presented normal locomotor activity and basal skin temperature. Likewise, the electrophysiological recordings showed a significant decrease in the number of dorsal horn neurons sensitive to noxious thermal stimuli in aquaporin-4 knockout mice. Moreover, latencies to thermal stimuli were significantly prolonged in a subset of dorsal horn wide-dynamic-range neurons. Taken together, these results suggest that aquaporin-4 plays a role in the processing of nociception.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1873-2747
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| pubmed:author | |
| pubmed:copyrightInfo |
2010 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
20
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| pubmed:volume |
83
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
298-303
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| pubmed:meshHeading |
pubmed-meshheading:20851747-Action Potentials,
pubmed-meshheading:20851747-Animals,
pubmed-meshheading:20851747-Aquaporin 4,
pubmed-meshheading:20851747-Behavior, Animal,
pubmed-meshheading:20851747-Hindlimb Suspension,
pubmed-meshheading:20851747-Hot Temperature,
pubmed-meshheading:20851747-Hyperalgesia,
pubmed-meshheading:20851747-Mice,
pubmed-meshheading:20851747-Mice, Knockout,
pubmed-meshheading:20851747-Neurons,
pubmed-meshheading:20851747-Pain Measurement,
pubmed-meshheading:20851747-Pain Threshold,
pubmed-meshheading:20851747-Psychomotor Performance,
pubmed-meshheading:20851747-Rotarod Performance Test,
pubmed-meshheading:20851747-Spinal Cord
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| pubmed:year |
2010
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| pubmed:articleTitle |
Hypoalgesia in mice lacking aquaporin-4 water channels.
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| pubmed:affiliation |
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yi-Xue-Yuan Road, Shanghai 200032, PR China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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