Linked Life Data

20850977

Source:http://linkedlifedata.com/resource/pubmed/id/20850977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2010-10-18
pubmed:abstractText
Our previous studies demonstrated that two cytotoxic ?-nitrostyrene derivatives, 3,4-methylenedioxy-?-nitrostyrene (MNS) and 4-O-benzoyl-3-methoxy-?-nitrostyrene (BMNS) exhibit potent anti-platelet activities. In this study, a series of ?-nitrostyrenes were synthesized and subjected to anti-platelet aggregation assay and cytotoxicity assay. The mono- and di-substitutions on the B ring of BMNS tended to increase the anti-platelet activity and decrease the cytotoxic activity. Of these, compounds 19 and 24 exhibited the most potent inhibitory effects on thrombin- and collagen-induced platelet aggregation (IC(50)?0.7 ?M) without significant cytotoxicity on a human cancer cell line (up to 20 ?M). Further studies indicated that compounds 19 and 24 inhibited platelet aggregation via prevention of glycoprotein IIb/IIIa activation. The potent and novel effects of BMNS derivatives make them attractive candidates for the development of new anti-platelet agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1464-3391
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7621-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The synthesis and biologic evaluation of anti-platelet and cytotoxic ?-nitrostyrenes.
pubmed:affiliation
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan. pewehs@mail.cgu.edu.tw
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't