| pubmed-article:20850384 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20850384 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:20850384 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:20850384 | lifeskim:mentions | umls-concept:C0034793 | lld:lifeskim |
| pubmed-article:20850384 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:20850384 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20850384 | pubmed:dateCreated | 2010-11-8 | lld:pubmed |
| pubmed-article:20850384 | pubmed:abstractText | B cell tolerance is regulated by receptors that modulate B cell receptor signaling, such as Fc gamma receptor IIb (Fc?RIIb; CD32b) and complement receptors (CR) 1 and 2. Deficiency in these receptors may contribute to autoimmunity. To address this we have investigated the receptor expression in healthy individuals in comparison with rheumatoid arthritis (RA) patients. In healthy subjects we found that women had overall lower Fc?RIIb expression on B cells than men that significantly decreased with age. RA patients had fewer Fc?RIIb, CR1 and CR2 positive B cells and decreased receptor expressions compared to healthy subjects. Further, the RA B cells displayed a significantly increased proliferative response when cultured with interleukin-2 in vitro. In summary, the dysregulated B cells in RA are associated with lower Fc?RIIb, CR1 and CR2 levels. The reduced Fc?RIIb expression on B cells in women may influence the increased frequency of autoimmunity in women. | lld:pubmed |
| pubmed-article:20850384 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20850384 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20850384 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20850384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20850384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20850384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20850384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20850384 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20850384 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20850384 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20850384 | pubmed:issn | 1521-7035 | lld:pubmed |
| pubmed-article:20850384 | pubmed:author | pubmed-author:KleinauSandra... | lld:pubmed |
| pubmed-article:20850384 | pubmed:author | pubmed-author:LindqvistUlla... | lld:pubmed |
| pubmed-article:20850384 | pubmed:author | pubmed-author:MattPeterP | lld:pubmed |
| pubmed-article:20850384 | pubmed:author | pubmed-author:ProkopecKajsa... | lld:pubmed |
| pubmed-article:20850384 | pubmed:author | pubmed-author:RhodinerMiaM | lld:pubmed |
| pubmed-article:20850384 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20850384 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20850384 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:20850384 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20850384 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20850384 | pubmed:pagination | 322-9 | lld:pubmed |
| pubmed-article:20850384 | pubmed:meshHeading | pubmed-meshheading:20850384... | lld:pubmed |
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| pubmed-article:20850384 | pubmed:meshHeading | pubmed-meshheading:20850384... | lld:pubmed |
| pubmed-article:20850384 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20850384 | pubmed:articleTitle | Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis. | lld:pubmed |
| pubmed-article:20850384 | pubmed:affiliation | Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. | lld:pubmed |
| pubmed-article:20850384 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20850384 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:20850384 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2213 | entrezgene:pubmed | pubmed-article:20850384 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20850384 | lld:entrezgene |
