Linked Life Data

20850384

Source:http://linkedlifedata.com/resource/pubmed/id/20850384

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-11-8
pubmed:abstractText
B cell tolerance is regulated by receptors that modulate B cell receptor signaling, such as Fc gamma receptor IIb (Fc?RIIb; CD32b) and complement receptors (CR) 1 and 2. Deficiency in these receptors may contribute to autoimmunity. To address this we have investigated the receptor expression in healthy individuals in comparison with rheumatoid arthritis (RA) patients. In healthy subjects we found that women had overall lower Fc?RIIb expression on B cells than men that significantly decreased with age. RA patients had fewer Fc?RIIb, CR1 and CR2 positive B cells and decreased receptor expressions compared to healthy subjects. Further, the RA B cells displayed a significantly increased proliferative response when cultured with interleukin-2 in vitro. In summary, the dysregulated B cells in RA are associated with lower Fc?RIIb, CR1 and CR2 levels. The reduced Fc?RIIb expression on B cells in women may influence the increased frequency of autoimmunity in women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1521-7035
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
322-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis.
pubmed:affiliation
Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't