Linked Life Data

20849904

Source:http://linkedlifedata.com/resource/pubmed/id/20849904

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-11-10
pubmed:abstractText
Expression of leucine, leucine-37 (LL-37) is enhanced in keratinocytes of skin lesions with psoriasis. We examined serum LL-37 levels in patients with psoriasis vulgaris. Serum LL-37 levels in patients were higher than in normal controls, and were reduced after cyclosporine A treatment. In both groups, LL-37 and interleukin (IL)-17 levels inversely correlated. In patients, LL-37 levels correlated with interferon (IFN)-? and IL-10 levels. In controls, LL-37 levels inversely correlated with tumor necrosis factor (TNF)-?, IL-6, IL-1?, and IL-22 levels. IFN-?, IL-17, IL-22, TNF-?, IL-6, and IL-1? enhanced, and IL-10, IL-4, IL-13, and cyclosporine A suppressed, LL-37 secretion from keratinocytes and neutrophils. LL-37 enhanced IFN-?, IL-4, IL-13, and TNF-? secretion from CD3/CD28-stimulated T cells, suppressed TNF-?, IL-1?, IL-6, and IL-10 secretion from lipopolysaccharide-stimulated monocytes, and IL-17, IL-22, IL-1?, IL-6, and IL-10 secretion from CD3/CD28-stimulated T cells. LL-37 may sustain its production by enhancing IFN-? or reducing IL-10 production, while suppressing its production by reducing IL-17, IL-22, TNF-?, IL-1?, or IL-6 and enhancing IL-4 or IL-13 production. In patients, systemic LL-37 production is enhanced, and an IFN-?/LL-37-positive feedback loop may exist. In controls, negative feedback by LL-37 on TNF-?, IL-1?, IL-22, and IL-6 may exist. In both groups, negative feedback by LL-37 on IL-17 may exist. LL-37 may act as an effector and regulator.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1879-1166
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1161-71
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines.
pubmed:affiliation
Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan. nmk@med.teikyo-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't