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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2010-10-4
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pubmed:abstractText |
Estrogen depletion following menopause has been correlated with an increased risk of developing Alzheimer's disease (AD). We previously explored the beneficial effect of (-)-epigallocatechin-3-gallate (EGCG) on AD mice and found increased non-amyloidogenic processing of amyloid precursor protein (APP) through the ?-secretase a disintegrin and metallopeptidase domain 10 (ADAM10). Our results in this study suggest that EGCG-mediated enhancement of non-amyloidogenic processing of APP is mediated by the maturation of ADAM10 via an estrogen receptor-? (ER?)/phosphoinositide 3-kinase/Ak-transforming dependent mechanism, independent of furin-mediated ADAM10 activation. These data support prior assertions that central selective ER modulation could be a therapeutic target for AD and support the use of EGCG as a well-tolerated alternative to estrogen therapy in the prophylaxis and treatment of this disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Adam10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Protein Precursor,
http://linkedlifedata.com/resource/pubmed/chemical/Catechin,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Furin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/epigallocatechin gallate
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Federation of European Biochemical Societies. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
584
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4259-67
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pubmed:dateRevised |
2011-10-10
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pubmed:meshHeading |
pubmed-meshheading:20849853-ADAM Proteins,
pubmed-meshheading:20849853-Alzheimer Disease,
pubmed-meshheading:20849853-Amyloid Precursor Protein Secretases,
pubmed-meshheading:20849853-Amyloid beta-Protein Precursor,
pubmed-meshheading:20849853-Animals,
pubmed-meshheading:20849853-Catechin,
pubmed-meshheading:20849853-Cell Line,
pubmed-meshheading:20849853-Disease Models, Animal,
pubmed-meshheading:20849853-Estrogen Receptor alpha,
pubmed-meshheading:20849853-Female,
pubmed-meshheading:20849853-Furin,
pubmed-meshheading:20849853-Humans,
pubmed-meshheading:20849853-Membrane Proteins,
pubmed-meshheading:20849853-Mice,
pubmed-meshheading:20849853-Models, Biological,
pubmed-meshheading:20849853-Neuroprotective Agents,
pubmed-meshheading:20849853-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20849853-Protein Processing, Post-Translational,
pubmed-meshheading:20849853-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20849853-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP.
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pubmed:affiliation |
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Tampa, FL 33613, USA. jfernan1@health.usf.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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