Linked Life Data

20849534

Source:http://linkedlifedata.com/resource/pubmed/id/20849534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-9-20
pubmed:abstractText
Interleukin-31 (IL-31), a recently discovered cytokine derived from T helper cells, is involved in chronic dermatitis and pruritus. This study demonstrates for the first time that the IL-31 receptor complex for IL-31 is substantially upregulated in human dermal microvascular endothelial cells after stimulation with interferon-? (IFN-?). Activation of the IL-31 receptor complex results in the induction of the intracellular ERK1/2 signaling pathway and downregulation of IFN-?-induced monokine induced by IFN-? expression. Inhibitor studies revealed that the IFN-?-induced IL-31RA upregulation is processed via JNK and PI3 kinase activation. In sum, our study points toward an interaction between the T(H) 1-derived cytokine IFN-? and the T(H) 2-derived cytokine IL-31 on endothelial cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1600-0625
pubmed:author
pubmed:copyrightInfo
© 2010 John Wiley & Sons A/S.
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
921-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Interferon-? induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells.
pubmed:publicationType
Letter, Research Support, Non-U.S. Gov't