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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-23
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pubmed:abstractText |
The distinction between dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) is a well-known challenge for dermatopathologists. Immunohistochemical stains have been used to augment routine histological examination to aid in differentiating DF from DFSP. Collagen triple helix repeat containing-1 (Cthrc1) was identified as a novel gene expressed in the adventitia and neointima on arterial injury. It is indicated to be a cell type-specific inhibitor of transforming growth factor-?, which in turn impacts collagen type I and III deposition, neointimal formation, and dedifferentiation of stem cells. Cthrc1 has also been shown to be highly active and potent in degrading extracellular matrix proteins and was found to be overexpressed in several malignant tumours, such as breast cancer and malignant melanoma. To our knowledge, however, expression of Cthrc1 in DFSP and DF has not been studied before.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1365-2133
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 The Authors. BJD © 2010 British Association of Dermatologists 2010.
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pubmed:issnType |
Electronic
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-40
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pubmed:meshHeading |
pubmed-meshheading:20849518-Adolescent,
pubmed-meshheading:20849518-Adult,
pubmed-meshheading:20849518-Aged,
pubmed-meshheading:20849518-Antigens, CD34,
pubmed-meshheading:20849518-Biological Markers,
pubmed-meshheading:20849518-Child,
pubmed-meshheading:20849518-Child, Preschool,
pubmed-meshheading:20849518-Dermatofibrosarcoma,
pubmed-meshheading:20849518-Diagnosis, Differential,
pubmed-meshheading:20849518-Extracellular Matrix Proteins,
pubmed-meshheading:20849518-Female,
pubmed-meshheading:20849518-Histiocytoma, Benign Fibrous,
pubmed-meshheading:20849518-Humans,
pubmed-meshheading:20849518-Immunohistochemistry,
pubmed-meshheading:20849518-Infant,
pubmed-meshheading:20849518-Male,
pubmed-meshheading:20849518-Matrix Metalloproteinase 11,
pubmed-meshheading:20849518-Middle Aged,
pubmed-meshheading:20849518-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Collagen triple helix repeat containing-1 in the differential diagnosis of dermatofibrosarcoma protuberans and dermatofibroma.
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pubmed:affiliation |
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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